Coated microneedle arrays for transcutaneous delivery of live virus vaccines
نویسندگان
چکیده
منابع مشابه
Fabrication of polymeric microneedle arrays containing Amphotericin-B for transdermal drug delivery
Background and Aim: Drug delivery through the microneedle array has been considered as an easy and non-invasive method in recent years. The purpose of this study was to design and construct an array of biodegradable polymeric microneedles containing Amphotericin-B to introduce this system and its use in the treatment of cutaneous lesions caused by Leishmania major parasite inoculation as a mode...
متن کاملCharacterization of Polymeric Microneedle Arrays for Transdermal Drug Delivery
Microfabrication of dissolvable, swellable, and biodegradable polymeric microneedle arrays (MNs) were extensively investigated based in a nano sensitive fabrication style known as micromilling that is then combined with conventional micromolding technique. The aim of this study was to describe the polymer selection, and optimize formulation compounding parameters for various polymeric MNs. Inve...
متن کاملHydrogel-Forming Microneedle Arrays for Enhanced Transdermal Drug Delivery
Unique microneedle arrays prepared from crosslinked polymers, which contain no drug themselves, are described. They rapidly take up skin interstitial fluid upon skin insertion to form continuous, unblockable, hydrogel conduits from attached patch-type drug reservoirs to the dermal microcirculation. Importantly, such microneedles, which can be fabricated in a wide range of patch sizes and micron...
متن کاملTransdermal Influenza Immunization with Vaccine-Coated Microneedle Arrays
BACKGROUND Influenza is a contagious disease caused by a pathogenic virus, with outbreaks all over the world and thousands of hospitalizations and deaths every year. Due to virus antigenic drift and short-lived immune responses, annual vaccination is required. However, vaccine coverage is incomplete, and improvement in immunization is needed. The objective of this study is to investigate a nove...
متن کاملImmunization by vaccine-coated microneedle arrays protects against lethal influenza virus challenge.
Influenza prophylaxis would benefit from a simple method to administer influenza vaccine into skin without the need for hypodermic needles. In this study, solid metal microneedle arrays (MNs) were investigated as a system for cutaneous vaccine delivery using influenza virus antigen. The MNs with 5 monument-shaped microneedles per array were produced and coated with inactivated influenza virus A...
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ژورنال
عنوان ژورنال: Journal of Controlled Release
سال: 2012
ISSN: 0168-3659
DOI: 10.1016/j.jconrel.2011.12.026